The Earliest Formal Research Shows a Genetic Link for Migraines
Research dating back to 1995
from Charing Cross and Westminster Medical School indicatesthat having “first-degree” relatives with migraine will significantly increase migraine risk – raising it anywhere from 1.4 to nearly 4 times. This affected both aura- and non-aura migraines.
Interestingly, the study also found that the spouses of those who suffer migraine without aura also had a significantly higher likelihood of migraine without aura themselves. The researchers concluded that migraine with aura is likely determined principally by genetics.
On the other hand, migraine without aura may originate partly or largely from environmental factors.
The Link Between Genes and Migraines
The answer to whether you can inherit migraine problems from your parents or grandparents is unclear. Substantial research points to a link between certain genetic traits and developing migraines. However, not everyone with these genes suffers from migraines, and there are numerous environmental triggers to take into account as well.
When one parent suffers from migraine, children have a 50% risk of also developing it. If both parents have recurring migraines, their kids have a 75% risk of suffering from migraines in the future. In fact, over 80% of people who have migraines also have close family members who deal with the condition. This doesn’t mean that having problems with migraines is inevitable based on genetics, but it does prove that hereditary factors at least play a role.
This idea isn’t really surprising to doctors since many aspects of health have hereditary factors to consider. When your doctor asks whether you have any family members with kidney problems or high blood pressure, it’s because genes can increase your risk of developing issues in the future.
Twins Reveal Interesting New Directions in Migraine Research
Migraine research had long been limited by basic deficiencies in science’s knowledge of human genetics. In 2003, the human genome was mapped
for the first time, significantly increasing the potential of genetics to explain, predict – and ultimately, perhaps prevent – migraine and more.
In 2005, research in the Journal of Clinical Neurology
made surprising findings about migraine’s origin and prevalence. Up to 20 percentof the population experiences migraines: A landmark study in Korea
indicated about 20 percentof males and 24 percentof females were sufferers.
Not only did research in the early 2000s begin to identify individual genetic markers that may be associated with migraine, but it demonstrated a significant role of non-shared genes
in twins. Substantial differences in migraine prevalence across different countries were also noted.
Genetic Models of Migraine Continue to Develop
In 2007, research from the Archives of Neurology
took the previous lab work another step forward. Through additional studies using mice, as well as continuing investigation of genetic factors, a set of three genes were identified for familial hemiplegic migraine.
Familial hemiplegic migraine
is one type of migraine known to run in families. It is classified as an “aura migraine,” since a visible halo or aura is usually perceived by sufferers before the onset of full symptoms. Temporary numbness or weakness also typically occurs on one side of the body.
Familial hemiplegic migraine is one of the most severe forms of migraine – and also one of the easiest to diagnose because of its unusual symptoms, some of which can be permanent. In the future, it might become possible to target and “turn off” the responsible genes.
Recent Research Opens the Door to Future Migraine Treatments
More than a decade of work done since the Human Genome Project has substantially clarified the mysteries behind the common migraine. Genome-wide association studies
will soon make it possible to rapidly investigate the genetic correlations of migraine across entire populations of people.
The development of such studies also allows for meta-analysis – that is, analyzing the results of large numbers of studies, which themselves analyze the health status of thousands or tens of thousands of patients. Through these methods, we know more about migraine than we ever have before.
2012 research in the Journal of Headache Pain
continued to push toward effective identification of key factors involved in non-aura migraines and those with complicated, multi-gene factors. Multiple new gene factors were illuminated, many of which had never been suspected.
In August 2013, two major new studies appeared: One in the Journal of Head and Face Pain
and another in Nature Genetics
. Both studies continued to fill in the blanks on migraine, showing multiple new loci – a specific position on a chromosome – associated with migraine.
The Role of Environmental Triggers
It’s important to understand that your genes don’t trigger or cause any migraine attacks directly. If you’re having problems with migraines, there are always other factors involved. Also, having a specific gene doesn’t mean that you or your children will 100% develop migraines. Instead, your genes affect the way your body responds to certain situations.
Put simply, some people are more likely to have a migraine when faced with things such as stress, sadness, tiredness, and dehydration. Hereditary factors cause their bodies to react to specific triggers in a different way than most people. For example, many non-sufferers can enjoy coffee or cola to their heart’s content, but for people prone to getting migraines, the same drinks may push them over the edge into an attack.
Causes of migraines are hard to predict and very personal. Even family members frequently have different migraine triggers. For some people, not getting enough sleep or feeling stressed out brings on a migraine, whereas other suffers may experience symptoms after sleeping too much or eating certain foods.
The Correct Way to Look at Genetic Predisposition to Migraines
If you have an increased risk of developing migraines because your parents or other relatives also have them, does that mean that there’s nothing you can do to prevent them or that relief is impossible? Absolutely not. Here are three things you need to keep in mind:
No one has a 100% risk of developing migraines: If you don’t currently have problems with migraines, don’t worry about it. Instead, enjoy life and do the things you love. Don’t let the fear of migraines get in the way of achieving your personal or professional goals.
Identifying your triggers can really help: If you currently suffer from migraines, taking the time to discover your personal triggers can make a real difference. When they repeatedly appear after eating certain foods or not getting enough sleep, try to change your habits for a few weeks to notice if it helps.
Great treatment has nothing to do with your genes: Genetic makeup doesn’t mean you’re destined to migraine pain. There are many effective treatments for migraines, regardless of what type of triggers or genes you have.
Hereditary factors can give you a clue to why you developed migraines in the first place, but they don’t mean you’re stuck without options. There are tons of ways to find relief, especially with migraine professionals by your side.
Want Access to the Latest Migraine Treatments?
In the near future, groundbreaking genetic treatments for migraine may be possible. To get fast, long-lasting relief from migraine, however, you don’t have to wait until then: Simply visit the migraine specialist Miami trusts.
Science has proven conclusively that many forms of migraine arise due to genetic factors. That said, environment and overall health also playroles. Underlying health conditions can cause many types of severe headaches, including non-aura migraines.
These conditions might go unnoticed for months or years, worsening headache pain.
Miami Headache Institute
At the Miami Headache Institute, treatment always begins with a thorough and comprehensive diagnosis using the latest technology. Following a detailed, one-on-one assessment with leading migraine experts, each patient receives a customized plan of care.
With appropriate, tailored care, many patients achieve permanent relief from pain.
If you’re suffering from chronic headaches or migraines, don’t wait any longer. Join thousands of patients from throughout the Sunshine State who have worked with Miami Headache Institute to get permanent relief. We look forward to helping you.